在过过程中形成的包装床结构的特性:一个二维和三维模型
William Eales1,2, Chris J Price1,2, William Hicks3
1Department of Chemical and Process Engineering, University of Strathclyde, Glasgow G1 1XJ, UK.
概括
制药加工面临着聚集的挑战. 过床的建模揭示了过过程中颗粒包装如何影响干燥和聚合,从而使工艺设计得到改进.
科学领域:
- 制药工程 制药工程
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 在制药二次加工过程中的聚合增加了成本,需要额外的资源.
- 过过程中的颗粒接触可以导致在干燥过程中形成坚固的聚合物.
- 了解过床包装对于解决聚合问题至关重要.
研究的目的:
- 使用计算模型在过过程中模拟包装床的形成.
- 分析颗粒大小分布对包装和空隙形成的影响.
- 提供有关过,干燥和聚合过程的见解.
主要方法:
- 开发了二维和三维的计算模型.
- 模拟过使用圆形和球形颗粒与双模尺寸分布.
- 分析了包装统计,空隙形成,粒子间接触和透结构.
主要成果:
- 在模拟过床中,特征性的封装和空隙形成.
- 研究了粒子大小分布对床结构的影响.
- 量化了与聚合相关的粒子间接触和透途径.
结论:
- 开发的模型有助于了解过和干燥过程中聚合物的起源.
- 预测能力可以指导合理的过程设计,以尽量减少聚合.
- 这项研究为优化制药制造工艺提供了基础.
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