基于克罗恩病GLIM诊断的营养不良的快速评估
Longchang Huang1, Fu Niannian1, Yupeng Zhang1
1Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
全球营养不良领导倡议 (GLIM) 标准有效地识别了克罗恩病 (CD) 患者的营养不良. 一种使用HBI,BMI和手臂周长的新型诺米图为CD营养不良提供了快速诊断工具.
科学领域:
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 营养不良是克罗恩氏病 (CD) 患者的重要并发症,与健康状况不佳有关.
- 准确有效地识别营养不良对于管理CD患者至关重要.
研究的目的:
- 为了验证全球营养不良领导倡议 (GLIM) 在CD患者中诊断营养不良的标准.
- 开发一种快速而准确的诊断方法来诊断CD的营养不良.
主要方法:
- 一项涉及四家医院177名CD患者的研究比较了GLIM标准的有效性.
- 开发并使用与营养不良相关的独立因素验证了一个名ogram模型.
- 用歧视,校准和决策曲线分析来评估模型性能.
主要成果:
- GLIM标准与SGA标准保持良好的一致性,显示出高灵敏度和特异性 (AUC=0.84).
- 哈维-布拉德肖指数 (HBI) 评分,BMI和中上臂周长被确定为营养不良的独立预测因素.
- 开发的诺米图表显示出用于诊断营养不良的优秀歧视 (AUC=0.953).
结论:
- GLIM标准被验证为在CD患者中诊断营养不良的适当标准.
- HBI评分是CD中GLIM炎症标准的潜在指标.
- 在HBM nomogram提供了一个简单,快速,有效的方法来诊断CD患者的营养不良.
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