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Updated: Jul 16, 2025

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发现了循环素依赖性激酶2 (CDK2) 的选择性三级胺抑制剂

Mingshuo Zeng1, Jessica M Grandner1, Marian C Bryan2

  • 1Genentech Inc., South San Francisco, California 94080, United States.

ACS medicinal chemistry letters
|September 22, 2023
PubMed
概括

研究人员开发了一种选择性小分子抑制剂,化合物32,向循环素依赖激酶2 (CDK2) 用于癌症治疗. 这种强大的抑制剂在临床前模型中显示出显著的瘤生长抑制.

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