患有功能性半腹膜瘤的患者的高血压危机:对八类药物治疗的戏剧性反应
Omayma T Elshafie1, Abir C Bou Khalil1, Maha A Alshaibi2
1Department of Endocrinology, Sultan Qaboos Comprehensive Cancer Care and Research Centre (SQCCCRC), Muscat, Sultanate of Oman.
AACE clinical case reports
|September 22, 2023
概括
高剂量的八胺有效地治疗了一名患有由中枢性偏瘤引起的严重高血压危机的患者. 这种治疗在手术前迅速使血压和甲基荷兰胺水平正常化.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 一名患者出现了重度高血压危机 (260/150毫米血压) 产后.
- 怀疑是二次高血压,并通过 retroperitoneal 质量和升高的类甲醇胺 (93,000 pmol/L) 得到证实.
- 这种质量被确定为功能性中介质偏瘤 (PGL).
研究的目的:
- 报告在患有功能性中性偏瘤的患者中对八丁的显著临床和生化反应.
- 突出高剂量牛胺在管理与PGL相关的高血压危机中的有效性.
主要方法:
- 诊断涉及68-DOTA-octreotate PET/CT和血中甲基胺水平的测量.
- 治疗开始时使用高剂量的长效和短效八类药物.
- 在初始治疗后,进行了逆质的手术切除.
主要成果:
- 八类药物治疗导致血压正常化 (120/70 mm Hg) 和降低北上腺素水平 (6000 pmol/L) 在6周内.
- 在没有药物治疗的情况下,患者在手术后保持正常压力.
- 组织学证实了帕拉结瘤的诊断.
结论:
- 高剂量的奥克胺对患有PGL和染细胞瘤的严重高血压患者有价值.
- 对八二的反应是快速的,持续的,有效的,并与最小的副作用相关.
- 这是功能性介质PGL中首次报告的高血压危机病例,该病例已成功用octreotide治疗.
更多相关视频
08:55A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
Published on: April 17, 2019
17.7K
07:43Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
18.9K
相关概念视频
01:15Hypoglycemia and Glucagon
287
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
287
01:28Esophageal Varices-II: Clinical Features and Management
86
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
86