改变的听觉过程模式预测了老年人的认知衰退:随着年龄的增长,不同的模式
Junjie Yang1, Xiaochen Tang1, Shaohui Lin1
1Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in aging neuroscience
|September 22, 2023
概括
变化的听觉不匹配消极性 (MMN) 的老年人表现出认知能力下降. 这种电生理学测量提供了一个有前途的查工具,用于识别与年龄有关的认知障碍风险的个体.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 认知心理学 认知心理学
背景情况:
- 老年人听力障碍与痴呆症风险增加有关.
- 听觉处理缺陷可能会在认知衰退之前出现.
- 不匹配负面性 (MMN) 提供了对中央审计处理的洞察力.
研究的目的:
- 为了调查是否妥协的MMN指数预测老年人的认知能力下降.
- 探索MMN作为认知障碍的电生理学标志物.
主要方法:
- 108名居住在社区的老年人接受了认知测试 (RBANS) 和EEG.
- 听觉不匹配负面性 (MMN) 使用听觉奇怪范式进行测量.
- 评估是在基线和12个月后的随访时进行的.
主要成果:
- 在年轻老年人中,认知能力下降与MMN峰值幅度降低和前向转移的延迟相关.
- 年长的成年人表现出延迟的MMN延迟,没有幅度变化.
- 随着年龄的增长,MMN的峰值幅度下降,特别是在70-80岁的年龄范围内.
结论:
- 改变的MMN模式在老化阶段被观察到,并预测认知能力下降.
- MMN是老年人认知障碍的潜在电生理学预测因子.
- 需要对MMN的神经机制和老化影响进行进一步的研究.
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