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在PTMC/交联PEGDA混合物的体外酶降解

Wei Li¹, Meina Lin¹, Chenchao Wang²

¹Liaoning Research Institute of Family Planning, The Affiliated Reproductive Hospital of China Medical University, Shenyang, China.

Frontiers in bioengineering and biotechnology

|September 22, 2023

概括

与聚乙烯甘二烯酸盐 (PEGDA) 进行交叉链接,提供了一种简单的方法来控制其降解率. 这一战略增强了PTMC的优势.

科学领域:

聚合物科学聚合物科学
生物材料工程生物材料工程
可降解的聚合物

背景情况:

聚1,3-三甲碳酸 (PTMC) 是一种生物相容和可降解的聚合物.
控制PTMC的降解率对于其应用至关重要.
现有的PTMC交叉连接策略需要提高方便性和控制性.

研究的目的:

为PTMC制定一个简单有效的交叉链接策略.
为了研究与聚乙烯甘二烯酸盐 (PEGDA) 交叉链接对PTMC特性的影响.
为了评估PTMC/PEGDA混合物的体外酶降解.

主要方法:

准备了PTMC和光活性PEGDA的混合物.
混合物通过使用紫外线进行光聚合,以创建交叉连接网络.
分析了物理性质 (凝分量,胀程度) 和在脂酶溶液中的体外酶降解.

主要成果:

增加的PEGDA含量导致PTMC/PEGDA混合物中的凝分数较高,胀程度较低.
降解发生在脂酶溶液中的表面侵蚀.
紫外线交叉链接的PEGDA显著改善了PTMC对脂酶侵蚀的抵抗力,更高的交叉链接减少了质量损失.

结论:

将PTMC与PEGDA混合和交叉链接是一种简单有效的方法来定制其降解率.
交叉连接密度直接影响PTMC的侵蚀抵抗和降解行为.
这种方法为开发可调节可降解的PTMC基材料提供了一个有前途的途径.

关键词:

在PEGDA的基础上,PEGDA是PEGDA.紫外线交叉连接的交叉连接酶性降解酶性降解脂酶脂酶是一种聚三甲烯碳酸) 是一种聚三甲烯碳酸.

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