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模板MRI扫描可靠地近似个体和群体层面的tES和TMS电场诱导在电机和前额回路的电场

Jennifer Y Cho¹, Sybren Van Hoornweder², Christopher T Sege³

¹Department of Neuroscience, Medical University of South Carolina, Charleston, SC, United States.

Frontiers in neural circuits

|September 22, 2023

概括

模板大脑模型可靠地估计跨刺激跨诊断的E字段. MNI-152模板足够地捕捉了集团级别的差异,以便准确的电场建模.

科学领域:

神经科学是一个神经科学.
计算建模计算建模

背景情况:

电场 (E-field) 建模有助于理解皮层目标的跨磁刺激 (TMS) 和跨电刺激 (tES).
对于准确的电子场建模,通常需要单个MRI扫描.

研究的目的:

评估使用模板大脑 (MNI-152,Ernie) 的E字段模型是否可以可靠地近似组级E字段.
为了评估195个不同诊断的个体的电子场建模准确性.

主要方法:

使用CHARM-SimNIBS 4.0.0管道用于TMS和tES的788 E-field计算模型.
在每位参与者4个模型中利用了运动和前额关的目标.
进行 permutation 分析以确定 E 场稳定点.

主要成果:

在个人,MNI-152和Ernie扫描之间,集团级E字段没有显著差异.
观察到TMS诱导的E场大小的显著诊断变化 (例如,焦虑与对照).
电子场稳定点在42至52名参与者之间.

结论:

MNI-152和Ernie模型提供了对群体平均TMS和tES诱导的E字段的有效和可靠估计.
MNI-152模板充分考虑了个体间的解剖学变异性.
基于模板的E字段建模是跨诊断研究的一个强有力的方法.

关键词:

在MNI-152中使用.在TMSMS中使用.电场 (E-field) 建模模型有限元素方法 (FEM)非侵入性大脑刺激的非侵入性大脑刺激 tDCSCS 是一个很好的方法.这就是它.模板MRI扫描模板MRI扫描

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