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[F]FMPEP-d的自动放射合成用于大麻素受体PET成像

Huailei Jiang^1,2,3, Yan Guo^1,2,3, Otto Muzik^2,4

¹Cyclotron and Radiochemistry Core, Karmanos Cancer Institute Detroit, MI, USA.

American journal of nuclear medicine and molecular imaging

|September 22, 2023

概括

一种新的自动化方法成功地产生了PET追踪器[18F]FMPEP-d2用于成像大脑中的大麻素受体1 (CB1R). 这一进步使得使用正子发射断层扫描更好地可视化神经退行性疾病.

科学领域:

神经科学是一个神经科学.
放射化学放射化学是指辐射化学.
医疗成像医学成像

背景情况:

大麻素亚型1受体 (CB1R) 在中枢神经系统中起着至关重要的作用.
改变CB1R密度与神经退行性疾病有关.
阳位子发射断层扫描 (PET) 能够实现非侵入性成像.

研究的目的:

开发一个完全自动化的PET追踪器[18F]FMPEP-d2.2.的放射合成.
评估[18F]FMPEP-d2用于成像CB1R密度的可行性.
确保追踪器符合患者使用的临床标准.

主要方法:

使用Synthra RNplus研究模块进行自动化放射合成.
针对[18F]FMPEP-d2生产的最佳反应条件.
对最终产品进行严格的质量控制测试.

主要成果:

总合成时间达到70分钟.
产生了[18F]FMPEP-d2 (n=3) 的 2.2 ± 0.1 GBq.
证明了极好的放射化学和化学纯度,满足所有释放标准.

结论:

[18F]FMPEP-d2的全自动放射合成是高效和可重复的.
标记器适用于CB1R的非侵入性PET成像.
这种方法促进了神经退行性疾病诊断的临床翻译.

关键词:

大麻素受体的受体是什么在PET成像中使用PET成像.[18F]FMPEP-d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d2d 自动化自动化自动化自动化放射性药物放射性药物放射性药物放射合成是放射合成的过程.

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