阻塞性睡眠呼吸暂停和:了解并发症的病理生理学
Manish Goyal1, Priyadarshini Mishra1, Harinder Jaseja2
1Department of Physiology, All India Institute of Medical Sciences Bhubaneswar, Odisha, India.
International journal of physiology, pathophysiology and pharmacology
|September 22, 2023
概括
阻塞性睡眠呼吸暂停 (OSA) 和经常同时存在. 与OSA相关的睡眠剥夺和低氧症可能会增加发作风险并加重,这表明这些疾病之间存在联系.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 内部医学 内部医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍存在的睡眠障碍,对健康有重大影响.
- 在OSA和之间存在很高的并发症率,但潜在的病理生理学仍然不清楚.
- 由于呼吸暂停/呼吸暂停事件,OSA的特征是间歇性低氧化和睡眠剥夺.
研究的目的:
- 探索阻塞性睡眠呼吸暂停和之间的病理生理机制.
- 阐明睡眠不足和间歇性低氧化在OSA和的并发症中的作用.
主要方法:
- 对OSA和的病理生理学现有文献的综述.
- 分析睡眠不足和低血对皮质刺激能力的影响.
- 检查REM睡眠剥夺在发症发生中的作用.
主要成果:
- 与OSA相关的睡眠剥夺和低氧症可以促进发症并加剧现有的.
- 快速眼动睡眠 (REMS) 剥夺,在OSA中更加明显,可能是发作的关键因素.
- 在OSA和之间可能存在双向关系和积极的反循环.
结论:
- 睡眠不足和间歇性缺氧是导致OSA和并发症的重要因素.
- 准OSA可能会改善控制,强调在患者中管理这种睡眠障碍的重要性.
- 对共享的病理生理机制进行进一步研究是有必要的,以改善患者的治疗结果.
相关概念视频
Sleep Apnea
177
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
177
Arteries of the Lower Limbs
206
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
206
Sleep-Wake Cycles
1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
Other Pulmonary Disorders
865
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
865
Narcolepsy
130
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
130


