针对神经退行性疾病治疗的基于PLGA的内鼻药物输送的近期进展
Nasim Aghaei Delche1, Reyhaneh Kheiri2, Behnam Ghorbani Nejad3
1Department of Biology, Payame Noor University, Tehran, Iran.
Iranian journal of basic medical sciences
|September 22, 2023
概括
基于Poly (乳酸-co-糖醇酸) 的纳米载体提供了一个有前途的途径,可以通过鼻腔向大脑输送药物,绕过血脑屏障治疗神经疾病.
科学领域:
- 神经科学是一个神经科学.
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 血脑屏障 (BBB) 显著限制了治疗中枢神经系统 (CNS) 疾病的疗效.
- 鼻内 (IN) 药物输送通过嗅觉系统提供直接通往大脑的途径,绕过BBB.
- 基于聚乳-co-glycolic 酸 (PLGA) 的纳米载体越来越多地被用于IN药物输送,因为它们的生物相容性和生物降解性.
研究的目的:
- 审查最近在基于PLGA的纳米载体中取得的进展,用于将鼻内药物输送到大脑.
- 为了突出这些纳米载体在治疗各种大脑疾病中的应用.
- 讨论这个领域的未来挑战和前景.
主要方法:
- 关于用于鼻内药物输送的基于PLGA的纳米载体的最近研究的文献综述.
- 分析纳米载体配方及其在临床前模型中的有效性.
- 关于阿尔茨海默病,帕金森病,脑瘤,缺血,,抑郁症和精神分裂症的应用信息的综合.
主要成果:
- PLGA纳米载体显示出通过鼻内途向大脑有效输送药物的潜力.
- 各种基于PLGA的配方已被开发和测试用于特定的神经疾病.
- 已经报告了针对阿尔茨海默氏症,帕金森症和其他中枢神经系统疾病的治疗剂的成功输送.
结论:
- 基于PLGA的纳米载体代表了用于治疗脑疾病的鼻内药物输送的可行策略.
- 需要进一步的研究来优化配方,并应对临床翻译的挑战.
- 使用PLGA纳米载体进行鼻内输送对未来的神经治疗有着显著的前景.
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