脊椎活动性结核病:当前更新
Rajasekaran Shanmuganathan1, Karthik Ramachandran1, Ajoy Prasad Shetty1
1Department of Spine Surgery, Ganga Medical Centre and Hospitals Pvt. Ltd., Mettupalayam Rd, Coimbatore, 641043 India.
North American Spine Society journal
|September 22, 2023
概括
脊柱结核病 (TB) 在全球范围内正在上升,经常影响脊柱. 早期诊断和多药化疗是关键,但耐药性对治疗构成重大挑战.
科学领域:
- 整形外科和传染性疾病
- 脊柱结核病流行病学和管理
背景情况:
- 脊柱结核病 (TB) 是最常见的肺外结核病形式,由于艾滋病毒,耐药性和迁移,全球的发病率不断增加.
- 它主要影响下胸部和胸脊椎,占所有肌肉骨结核病例的50%.
研究的目的:
- 系统地审查脊柱结核病的诊断,流行病学,病因学,管理和外科治疗.
- 分析治疗这种疾病的最新进展和挑战.
主要方法:
- 通过使用Cochrane系统评论数据库,EMBASE和PubMed进行了系统的文献搜索.
- 在过去10年内发表的研究,使用与脊柱结核病相关的特定医学主题标题 (MeSH) 术语进行分析.
主要成果:
- 标志包括渐进式崩,阴影症和由于脊椎和盘破坏而导致的神经缺陷.
- 诊断依赖于成像和实验室测试,组织诊断 (培养,组织学,PCR) 作为黄金标准.
- 不复杂的脊髓结核病可以通过多药化学疗法治疗;对于不稳定性,神经功能障碍或形,可以进行手术.
结论:
- 脊柱结核病的早期诊断和治疗产生了令人满意的临床结果.
- 药物耐药性的出现是"结束结核病战略"的一个主要障碍,需要严格遵守治疗方案.
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