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Updated: Jun 8, 2026

Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions
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Measuring Biomolecular DSC Profiles with Thermolabile Ligands to Rapidly Characterize Folding and Binding Interactions

Published on: November 21, 2017

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微尺度热泳中的非共价染料,用于研究RNA连接体相互作用和修饰

Elisabeth Kallert1, Malte Behrendt1, Ariane Frey1

  • 1Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University of Mainz Staudingerweg 5 55128 Mainz Germany barthels@uni-mainz.de.

Chemical science
|September 22, 2023
PubMed
概括

这项研究引入了一种使用微量热泳 (MST) 与非共价染料分析RNA的新方法. 这种方法简化了RNA相互作用研究和修饰识别.

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Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...