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Updated: Jul 16, 2025

Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
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在老鼠基因组中对非同义变异的基因约束

George Powell1,2, Michelle M Simon3, Sara Pulit4

  • 1Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK. gjp15@ic.ac.uk.

BMC genomics
|September 22, 2023
PubMed
概括

我们开发了一种新的指标,非同义观察预期比率 (NOER),用于测量小鼠的基因约束. 在小鼠基因中较高的约束与更多的淘汰现型和与人类疾病相关的相关性有关.

关键词:
鼠标模型 鼠标模型负选择选择 负选择选择有选择性的约束.同义和非同义突变的突变

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