口腔状细胞癌:现状和新兴方向
Yunhan Tan1,2, Zhihan Wang1, Mengtong Xu1
1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.
International journal of oral science
|September 22, 2023
概括
口腔状细胞癌 (OSCC) 是一种影响口腔健康的主要癌症. 了解其复杂的发展和当前的治疗方法对于改善患者的治疗结果和生存率至关重要.
科学领域:
- 在瘤学瘤学.
- 口腔医学是指口腔医学.
- 癌症生物学 癌症生物学
背景情况:
- 口腔状细胞癌 (OSCC) 占口腔癌的90%,显著影响生活质量.
- 预计到2040年,全球OSCC发病率将增加40%,这突显了迫切的公共卫生问题.
- 烟草,酒精,贝特尔 (BQ) 和人类乳头瘤病毒 (HPV) 等危险因素有助于口腔潜在恶性疾病 (OPMDs),这是OSCC的前体.
研究的目的:
- 审查OSCC瘤发生背后的复杂机制.
- 讨论目前OSCC和OPMD的治疗策略和预后标志物.
- 为该领域的研究和临床管理提供未来的前景.
主要方法:
- 对OSCC发展中的机制的文献综述.
- 对OSCC和OPMD的当前治疗干预措施的分析.
- 讨论预后因素和未来的研究方向.
主要成果:
- OSCC瘤发生是一个复杂的过程,涉及遗传变化,表观遗传变化和瘤微环境失调.
- 对于OSCC和OPMDs,存在各种治疗方法,包括化疗,辐射,免疫疗法和纳米医学.
- 确定治疗和预后因素是提高治疗疗效的关键.
结论:
- 对OSCC机制的全面理解对于开发有效的治疗方法和改善患者预后至关重要.
- 对治疗和预后因素的进一步研究将加强OSCC和OPMD的管理.
- 这一综述为未来对抗口腔癌的进展提供了基础.
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