氨基酸代谢分析研究揭示了糖尿病病的独特诊断模型
Jiao Wang1,2,3, Chunyu Zhou2,3,4, Qing Zhang5,6
1Department of Geriatric Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Amino acids
|September 22, 2023
概括
通过分析血液,尿液和唾液中的氨基酸 (AA) 概况,可以改善糖尿病病 (DKD) 的诊断. 改变的AA水平显示了与DKD进展相关的代谢变化,有助于早期检测.
科学领域:
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 糖尿病病 (DKD) 是糖尿病的严重并发症,也是导致死亡的主要原因.
- 需要准确的DKD诊断标记,需要对其代谢基础有更深入的了解.
研究的目的:
- 研究DKD患者中氨基酸 (AA) 代谢特征变化的研究.
- 通过代谢学方法识别用于DKD诊断的潜在生物标志物.
主要方法:
- 超高性能液态染色学 (UPLC-MS/MS) 双重质谱法用于分析代谢概况.
- 分析了来自DKD,2型糖尿病 (T2DM) 和健康对照患者的血,尿液和唾液样本.
- 后勤回归和接收器运行特征 (ROC) 分析被用于开发诊断模型.
主要成果:
- 在DKD患者中观察到血,尿液和唾液氨基酸水平的显著变化.
- 血西丁和氨酸的降低,尿中氨酸的增加,尿中西丁和氨酸的降低,以及唾液中氨酸的增加被确定.
- 基于AA档案的诊断模型实现了0.957的AUC和92.2%的准确性.
结论:
- 改变的氨基酸代谢概况与糖尿病病的进展有关.
- 一种利用血,尿液和唾液中的AA水平的新型诊断模型显示了DKD诊断的前景.
- 这种新陈代谢方法可能为检测DKD提供脏活检的非侵入性替代方案.
相关概念视频
Overview of Protein Metabolism
1.3K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.3K
Chronic Kidney Disease III: Interprofessional Care
28
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
28
Chronic Kidney Disease I: Introduction
20
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
20
Nephrotic Syndrome II : Assessment and Medical Management
8
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
8


