基因预测的雄激素特征和不良心脏标志物:一个性别特异的门德尔随机化研究
Jun Yu Chen1, Maddalena Ardissino1,2, Rohin K Reddy1
1National Heart and Lung Institute, Imperial College London, London, UK.
ESC heart failure
|September 22, 2023
概括
在女性中,基因预测的高生物可用丸激素与不良的心脏变化和心力衰竭风险增加有因果关系. 这项门德尔随机化研究突出了性别特异性的荷尔蒙对心血管健康的影响.
科学领域:
- 心血管遗传学 心血管遗传学
- 内分泌学 在内分泌学.
- 心脏衰竭研究研究
背景情况:
- 观察性研究表明,性激素水平与心力衰竭之间存在联系.
- 雄激素性激素在心血管健康中起作用,但因果关系尚不清楚.
- 门德尔随机化 (MR) 可以使用遗传变异来调查因果关系.
研究的目的:
- 调查雄激素性激素特征对心脏结构,功能和心力衰竭 (HF) 的因果关系.
- 利用性别特异性遗传变异和门德尔随机化 (MR) 进行因果推理.
- 检查激素特征和心血管结果之间的性别相关联.
主要方法:
- 从事与性激素结合球蛋白 (SHBG),总和生物可用相关的性别特异性遗传变异,来自英国生物银行GWAS数据.
- 使用逆变量加权MR作为主要分析方法.
- 在英国生物库参与者和外部队列中评估了与左心室喷射分数 (LVEF),体积 (LVEDV,LVESV),中风体积 (LVSV),心脏指数,心脏输出和HF的关联.
主要成果:
- 在女性中,更高的遗传预测生物可用与较低的LVEDV,LVESV,LVSV,心脏输出和心脏指数相关,以及更高的高血压风险.
- 在女性中,更高的基因预测SHBG与更大的LVEDV,LVESV和LVSV有关.
- 在男性中,更高的基因预测的总和生物可用与分别较低的LVESV和LVEF有关.
结论:
- 这项研究提供了女性亲雄激素性激素配置文件对不利的左心室结构和功能标志物的因果关系的证据.
- 这些发现表明,雄激素特征与女性心力衰竭之间存在联系,特别是女性心力衰竭与保留喷射分数的心力衰竭.
- 在男性中观察到类似关联的较弱证据.
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