相关实验视频

Updated: Jul 16, 2025

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

细胞外微RNA与减肥有关的系统性审查和元分析

Camilla H B Veie¹, Isabella M T Nielsen¹, Nanna L S Frisk¹

¹Department of Science and Environment, Roskilde University, Universitetsvej 1, 4000 Roskilde, Denmark.

|September 22, 2023

概括

减肥可以改善代谢健康,但需要特定的循环微RNA (miRNA) 生物标志物. 一项元分析发现miR-26a,miR-122和miR-223水平增加,而miR-142随着体重减轻而下降.

科学领域:

生物化学生物化学
遗传学遗传学是一个
代谢健康代谢健康

背景情况:

肥胖是心血管疾病和2型糖尿病的主要危险因素.
适度减肥 (5-15%) 可以改善代谢健康.
循环中的microRNAs (miRNAs) 是代谢变化的潜在生物标志物,但体重减轻的特定标志物尚未确立.

研究的目的:

系统地审查和元分析与干预驱动的减肥相关的微RNA (miRNA) 物种水平.
为了确定可复制的循环miRNA生物标志物,表明减肥效率.

主要方法:

按照PRISMA指南进行系统审查和元分析.
在PubMed和SCOPUS数据库进行的搜索.
在选697篇文章后包括27篇全文文章;进行了质量和偏见评估.
在三项或更多研究中调查的miRNA物种的元分析.

主要成果:

在减肥后,miR-26a,miR-122和miR-223水平显著增加.
在减肥后,miR-142水平显著下降.
miR-221,miR-140,miR-122和miR-146没有显示体重减轻的显著变化.

结论:

很少有特定的微RNA (miRNA) 物种表现出随着体重减轻的循环中可复制的变化.
已识别的miRNAs (miR-26a,miR-122,miR-223,miR-142) 可能作为与减肥相关的代谢健康变化的潜在生物标志物.

关键词:

减肥手术减肥手术是什么生物标志物生物标志物体重恒温身体体重恒温饮食饮食饮食饮食细胞外RNARNA是什么液体活检活检液体活检代谢综合征代谢综合征这是一个微型RNA.没有编码的RNA.非侵入性诊断是一种非侵入性诊断.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖减肥减肥减肥减肥减肥减肥

更多相关视频

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Published on: April 26, 2019

相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...