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在HNSCCs潜在的microRNA预后签名:一个系统的审查

Mario Dioguardi¹, Francesca Spirito¹, Giovanna Iacovelli¹

¹Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, Italy.

|September 22, 2023

概括

这项研究研究了microRNAs (miRNAs) 作为头部和部状细胞癌 (HNSCCs) 的潜在生物标志物. 虽然特定的miRNAs显示出希望,但需要进一步的研究来确认它们在HNSCC预后中的临床实用性.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物标志物生物标志物

背景情况:

头部和部状细胞癌 (HNSCCs) 具有显著的死亡率和发病率,通常在晚期被诊断出来.
微RNAs (miRNAs) 参与HNSCC的发展和进展,作为瘤基因或瘤抑制剂.
患者样本中的独特miRNA模式为HNSCC诊断,预后和治疗向提供了潜力.

研究的目的:

确定对HNSCC.中的有前途的miRNA进行系统审查和临床试验.
使用顶部miRNAs创建分子签名,以评估来自癌症基因组图谱 (TCGA) 的HNSCC队列中的预后价值.

主要方法:

在PubMed,Scopus,Science Direct和Cochrane图书馆搜索了"签名microRNA"和"HNSCC"等关键词.
包括15个系统文献评论和76个预后临床报告.
根据患者数量选择了三种高度研究的miRNAs (miR-21,miR-155,miR-375) 来进行基于患者数量的分子生物签名.

主要成果:

在比较高和低的组织表达水平时,miR-21,miR-155和miR-375的分子生物签名显示总生存 (OS) 的危险比 (HR) 为1.28 (95% CI: [0.95,1.72]).
这表明这些miRNA在HNSCC中的潜在预后作用.

结论:

目前的证据表明,miRNAs对HNSCC查和临床管理具有潜在的预后价值.
建议进行大规模的队列研究,以验证这些miRNA单独或组合的临床实用性,用于HNSCC的随访和治疗.

关键词:

在HNSCC中,我们可以看到.这是一个微型RNA.口腔癌是指口腔癌的发生.风险因素的风险因素是什么

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