相关实验视频

Updated: Jul 16, 2025

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

A Murine Ommaya Xenograft Model to Study Direct-Targeted Therapy of Leptomeningeal Disease

Published on: January 29, 2021

脑脊髓液用于治疗来自固体瘤的瘤转移

Archit B Baskaran¹, Ankush Bhatia², Priya Kumthekar³

¹Resident, Department of Neurology, The University of Chicago Medicine, Chicago, IL 60637, USA.

Future oncology (London, England)

|September 22, 2023

概括

导管内疗法提供了一个可行的治疗选择,为leptomeningeal转移 (LM),尽管糟糕的生存结果. 了解疗效和毒性是未来LM治疗策略的关键.

科学领域:

神经瘤学神经瘤学
临床药理学临床药理学

背景情况:

瘦骨内转移 (LM) 显著增加患者的发病率和死亡率.
导管内疗法是LM的关键治疗方式.

研究的目的:

巩固和分析目前关于内治疗的LM的研究.
描述用于LM的内药物的演变趋势.

主要方法:

对48项临床试验的系统审查,这些试验涉及内药物治疗LM.
结果被表格化,并描述了治疗剂的趋势.

主要成果:

已经研究了一系列的内毒剂,包括细胞毒剂,长效配方,向抗体和放射性核素.
结果报告在试验中不一致.
在报告时,LM的生存率仍然很低.

结论:

导管内治疗是一种可行的LM治疗选择.
进一步了解有效性,安全性和毒性对于优化它们的使用至关重要.
这些疗法可能在未来的LM治疗模式中发挥重要作用.

关键词:

在CSF的CSF中,化学疗法化疗化疗在内,内.勒普托门内尔转移 (leptomeningeal metastases) 是一种转移.

更多相关视频

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research

Author Spotlight: Assessing the Potential of Circulating Tumor Cells in Leptomeningeal Disease Research

Published on: March 29, 2024

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

相关概念视频

Drug Delivery: Parenteral Route

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...