与年龄相关的干性黄斑退行症的治疗:一篇综述
Shenouda Girgis1, Lawrence R Lee1,2,3
1City Eye Centre, Brisbane, Australia.
Clinical & experimental ophthalmology
|September 22, 2023
概括
与干燥衰老相关的黄斑变性 (dAMD) 的新疗法正在出现,包括补充通路抑制剂,在减少地理缩生长方面显示出有前途. 本综述更新了用于dAMD管理的临床试验.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 临床研究 临床研究
背景情况:
- 与年龄相关的黄斑变性 (AMD) 显著影响全球健康.
- 抗血管内皮生长因子 (抗VEGF) 治疗转化了新血管AMD (nAMD) 治疗.
- 干性AMD (dAMD) 目前缺乏经批准的治疗方法,这促使进行了广泛的研究.
研究的目的:
- 审查目前对干性AMD治疗的临床研究.
- 提供旨在预防地理缩 (GA) 进展的治疗方法的最新信息.
主要方法:
- 对正在进行的dAMD临床试验的文献综述.
- 对正在研究的治疗类别的分析.
- 专注于针对地理缩 (GA) 的治疗方法.
主要成果:
- 几种治疗类别正在对dAMD进行临床试验.
- 内抗补剂因子在减少GA生长方面表现出3期疗效.
- 佩格塞塔科普兰和avacincaptad pegol是主要的候选人.
结论:
- 对于dAMD和GA预防,有前途的治疗途径正在出现.
- 补充通路的抑制显示出显著的潜力.
- 持续的研究对于开发有效的dAMD治疗至关重要.
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