通过集群分析得出的饮食模式及其与代谢功能障碍相关的肥胖性肝病严重程度的关联研究在西班牙裔患者中
Xiaotao Zhang1,2, Carrie R Daniel1, Valeria Soltero3
1Division of Cancer Prevention and Population Sciences, Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
The American journal of gastroenterology
|September 22, 2023
概括
快餐/肉类饮食模式与西班牙裔患者更严重的脂肪肝疾病 (MASLD) 有关. 基于植物的饮食可能有保护作用,强调了为这个高危人群量身定制的饮食干预措施的必要性.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 饮食是代谢功能障碍相关的脂肪性肝病 (MASLD) 的关键可改变的风险因素.
- 西班牙裔人口的患病率和严重程度最高.
- 有限的研究存在于饮食模式和MASLD的严重程度,特别是在西班牙裔社区.
研究的目的:
- 通过集群分析,识别患有MASLD的西班牙裔患者中普遍存在的饮食模式.
- 调查确定饮食模式与MASLD严重程度之间的关联.
主要方法:
- 从哈里斯县MASLD队列中对421名西班牙裔MASLD患者进行横截面分析.
- 基于食物频率调查问卷,K-Means集群分析来定义基于食物频率问卷的饮食模式.
- 多变量后勤回归用于评估与脂肪酸,脂肪肝炎和纤维化的关联.
主要成果:
- 两种不同的饮食模式被确定:一种植物性食品/谨慎的模式和一种快餐/肉类的模式.
- 快餐/肉类模式显示,与植物食品/谨慎模式相比,更严重的肥胖症的几率增加了2.47倍.
- 在饮食模式和氨基转移酶,代谢功能障碍相关的脂肪肝炎或纤维化之间没有发现显著的关联.
结论:
- 快餐/基于肉类的饮食模式与西班牙裔MASLD患者严重脂肪酸的几率增加有关.
- 基于植物的饮食模式可能有助于预防MASLD的严重程度.
- 了解这些模式对于为患有MASLD的西班牙裔个人开发有针对性的饮食干预措施至关重要.
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