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洞察肠道微生物组,其代谢物和心力衰竭之间的关联
Adilah F Ahmad1,2, Jose A Caparrós-Martin3, Nicola Gray4
1Department of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medial Research, Perth, Western Australia, Australia.
American journal of physiology. Heart and circulatory physiology
|September 22, 2023
概括
与健康个体相比,心力衰竭患者表现出肠道细菌多样性的减少和微生物代谢物的改变. 这些变化,包括枯竭的Clostridia,表明了心力衰竭 (HF) 的新诊断和治疗目标.
科学领域:
- 微生物组研究 微生物组研究
- 心血管疾病 心血管疾病
- 代谢学 代谢学 代谢学
背景情况:
- 心力衰竭 (HF) 是一个重要的全球健康问题,代表了许多心血管疾病的末期阶段.
- 了解肠道微生物组在HF病变发生中的作用,对于开发新的治疗策略至关重要.
- 以前的研究表明肠道失调和心血管健康之间存在联系,但高频率的具体变化需要进一步调查.
研究的目的:
- 与健康对照组相比,研究心力衰竭 (HF) 患者肠道微生物组合和相关代谢物的变化.
- 检查与HF相关的炎症,代谢和脂质学特征.
- 为了确定潜在的微生物和代谢生物标志物用于HF诊断和治疗.
主要方法:
- 一项观察性研究涉及73名HF患者 (左心室喷射率≤45%) 和59名健康志愿者.
- 在基线和6个月后随访时采集血液和便样本.
- 分析肠道微生物群的多样性,微生物组成,血/血清代谢物,炎症标志物和脂质组形状.
主要成果:
- 在随访时,HF患者表现出肠道细菌α多样性的减少 (P=0.004) 和便微生物群中开始性Clostridia的枯竭.
- 在HF患者中观察到血乙酸,三甲基胺-N-氧化物 (TMAO),可溶性CD14 (sCD14) 和可溶性CD163 (sCD163) 含量显著增加.
- 与健康对照组相比,HF患者呈现出明显的代谢和脂质组状况.
结论:
- 在HF患者和健康个体之间,肠道微生物组合和代谢物生产存在显著差异.
- 改变的肠道微生物群,特定的代谢物 (例如,乙酸,TMAO) 和炎症标志物与HF相关.
- 这些发现突出了治疗干预和心力衰竭管理诊断工具的潜在新型微生物和代谢点.
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