在心肌缺血期间实时体内胸部脊柱谷氨酸检测真实时间
Siamak Salavatian1,2,3, Elaine Marie Robbins3, Yuki Kuwabara1
1Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
American journal of physiology. Heart and circulatory physiology
|September 22, 2023
概括
研究人员开发了一种灵活的探针,可以实时测量脊柱谷氨酸. 这种新工具可以监测心脏病期间的神经活动,例如缺血-再输血损伤.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 心脏病学 心脏病学
背景情况:
- 谷氨酸是脊髓中的主要刺激性神经递质.
- 脊柱谷氨酸监测提供了对神经处理的洞察力,可以作为神经活动增加的生物标志物,特别是在受损的吸收系统中.
- 功能障碍的脊柱谷氨酸信号传递与各种神经疾病有关.
研究的目的:
- 开发和验证一种新的多通道柔性谷氨酸感应探针,用于实时,体内测量大型动物模型中的细胞外谷氨酸度.
- 评估探针在脊髓中的灵敏度,特异性和性能.
- 应用开发的传感技术来监测心肌缺血-回 (I/R) 损伤期间的脊柱谷氨酸酸变化.
主要方法:
- 开发一个定制的,多通道的柔性谷氨酸感应探头.
- 在体外和体外验证探头灵敏度和特异性的验证.
- 在体内评估探针在猪脊髓中的机械和传感性能.
- 在诱导心肌 I/R 损伤期间使用探针测量脊柱谷氨酸的应用.
主要成果:
- 灵活的探针几乎可以立即检测谷氨酸,并允许持续监测.
- 在体内评估证实了探针在猪脊髓中的可靠性能.
- 这项研究成功地检测出肌肉心脏I / R损伤期间脊柱谷氨酸信号的增加,与交感激活和潜在的心律失常相关.
结论:
- 一种新的灵活的谷氨酸感应探针可以实时在体内监测大型动物的脊柱谷氨酸.
- 这种技术为评估心脏-脊柱通路所涉及的心脏事件期间脊柱神经网络活动提供了有价值的工具.
- 这些发现凸显了脊柱谷氨酸作为影响心脏干预期间神经处理的条件的生物标志物的潜力.
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