出生体重影响心脏结构,功能和疾病风险:证据表明存在因果关系
Maddalena Ardissino1,2, Alec P Morley2, Eric A W Slob3,4,5,6
1National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK.
European heart journal
|September 22, 2023
概括
低出生体重,即使独立于子宫内环境,也会因果上增加心血管疾病的风险. 低出生体重的个体可能会从早期的,有针对性的心血管疾病预防策略中受益.
科学领域:
- 遗传学 是一个遗传学.
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 低出生体重是已知的晚年心脏代谢疾病的风险因素.
- 以前的研究没有区分直接的胎儿遗传影响和间接的母亲环境对出生体重的影响.
- 了解这些不同的途径对于确定与心血管疾病的因果关系至关重要.
研究的目的:
- 调查出生体重,特别是直接对胎儿的影响和心血管疾病风险之间的因果关系.
- 检查直接胎儿效应驱动的出生体重与心脏结构和功能之间的关系.
- 将胎儿基因组对出生体重的影响与子宫内环境因素分开.
主要方法:
- 使用全基因组关联研究总结统计数据进行门德尔随机化 (MR) 分析.
- 提取与出生体重无关的,全基因组显著的单核酸多态的提取 (整体和直接的胎儿影响).
- 逆变量加权MR应用于心血管疾病结局和心脏指标,并对多次比较进行本雅明尼-霍赫伯格校正.
主要成果:
- 较低的遗传预测出生体重,仅考虑直接的胎儿影响,与冠状动脉疾病风险增加有关 (OR 1.21).
- 对出生体重的直接胎儿影响与心脏腔体积较小和中风体积较低有关.
- 也观察到较高的心脏收缩率与较低的直接胎儿效应出生体重相关.
结论:
- 出生的体重受胎儿基因的影响,在心血管疾病中起因作用,独立于子宫内环境.
- 这些发现支持在低出生体重的个体中需要早期心血管疾病预防策略.
- 针对性的干预措施可能是有益的,无论经历的妊娠条件.
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