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吸烟对血栓抗脂综合征的影响:10年前性队列研究
Hui Jiang1, Can Huang1,2, Yu Shi1
1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Rheumatology (Oxford, England)
|September 22, 2023
概括
吸烟与更多的动脉血栓事件和患有血栓性抗脂综合征 (TAPS) 的患者的更糟糕结果有关. 应强烈建议TAPS吸烟者戒烟,以改善他们的预后.
科学领域:
- 心血管医学 心血管医学
- 类风湿病学 类风湿病学
- 血液学 血液学 血液学
背景情况:
- 吸烟是已知的自身免疫性疾病的风险因素之一.
- 吸烟对血栓性抗脂综合征 (TAPS) 的具体影响尚不清楚.
研究的目的:
- 研究吸烟与TAPS的临床特征和预后之间的关联.
- 为了确定吸烟是否影响TAPS患者血栓事件的发生和严重程度.
主要方法:
- 从2013年到2022年进行了一项前性队列研究.
- 分析了297名TAPS患者,包括82名吸烟者和215名非吸烟者.
- 倾向分数匹配被用来比较57名吸烟者与57名非吸烟者.
主要成果:
- 患有TAPS的吸烟者在诊断时表现出更高的心血管风险因素,动脉血栓事件 (特别是心肌梗塞和内脏/外周血栓),以及随访期间的复发性动脉事件.
- 即使对心血管风险因素进行了匹配,吸烟者也显示动脉血栓的患病率更高,特别是在大脑,心血管和视网膜血管区域.
- 吸烟者经历的器官损伤结果明显更差,APS损伤指数得分更高,特别是影响心血管,胃肠道和眼科系统.
结论:
- 吸烟与动脉血栓事件的风险增加和TAPS患者的预后较差有关.
- 强烈鼓励TAPS患者戒烟,以减轻疾病进展和改善结果.
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