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鼻内mRNA-LNP接种疫苗可以保护仓鼠免受SARS-CoV-2感染

Gabriela Baldeon Vaca1, Michelle Meyer2,3, Ana Cadete1

  • 1Moderna Inc., Cambridge, MA, USA.

Science advances
|September 22, 2023
PubMed
概括

鼻内信使RNA (mRNA) 疫苗在呼吸道感染方面表现有前途. 这项对仓鼠的研究表明,鼻内mRNA疫苗有效地保护了SARS-CoV-2,减少了病毒载量和肺部损伤.

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Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...