在非月经妇女中意外的阴道出血和COVID-19疫苗接种
Kristine Blix1, Ida Laake1, Lene Juvet2
1Department of Method Development and Analytics, Norwegian Institute of Public Health, Oslo, Norway.
Science advances
|September 22, 2023
概括
接种COVID-19疫苗可能会增加非月经妇女的意外阴道出血. 绝经后,绝经前和绝经前妇女在接种疫苗后面临更高的风险,Spikevax在绝经前妇女中显示出比Comirnaty更高的风险.
科学领域:
- 生殖健康 生殖健康
- 疫苗学 疫苗学 疫苗学
- 流行病学 流行病学
背景情况:
- COVID-19疫苗接种和月经不规则之间的关系是一个新兴的研究领域.
- 非月经期妇女的阴道出血,包括绝经后和绝经前出血,需要进一步调查疫苗的副作用.
研究的目的:
- 调查COVID-19疫苗接种与非月经妇女意外阴道出血之间的关联.
- 量化在不同更年期阶段接种COVID-19疫苗后阴道出血的风险.
主要方法:
- 进行了一项包括绝经后,绝经前和绝经前妇女在内的队列研究.
- 在8-9个月的时间内,对自我报告的意外阴道出血进行了系统的数据收集.
- 风险评估比较了疫苗接种后4周和疫苗接种前4周的出血事件.
主要成果:
- 意外的阴道出血发生在3.3%的绝经后妇女,14.1%的绝经前妇女和13.1%的绝经前妇女中.
- 接种COVID-19疫苗与更年期后出血风险增加2-3倍有关.
- 在接种疫苗后的非月经期和绝经前妇女中,观察到意外阴道出血的风险增加了3-5倍.
- 与Comirnaty相比,Spikevax疫苗在绝经前妇女中显示出出血的风险高出32%.
结论:
- 接种COVID-19疫苗与不同绝经状态的非月经妇女意外阴道出血的风险增加有关.
- 特定的疫苗类型可能与出血事件有不同的关联.
- 需要进一步的研究来证实这些发现,并了解潜在的机制.
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