根据年龄来看,SARS-CoV-2 Omicron BA.5 获得了病原性
Brian Imbiakha1, Shahrzad Ezzatpour2, David W Buchholz1
1Department of Microbiology and Immunology, Cornell University, College of Veterinary Medicine, Ithaca, NY, 14853, USA.
Science advances
|September 22, 2023
概括
与BA.1不同的是,SARS-CoV-2的Omicron BA.5变种在小鼠中引起严重的疾病和死亡率. 这项研究确定了一种新的小鼠模型,用于研究Omicron BA.5的病变发生和开发对策.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 对SARS-CoV-2令人担忧的变种 (VOC) 的病理学研究因缺乏合适的动物模型而受到限制.
- 以前的Omicron变种 (BA.1,BA.2) 在K18-hACE2转基因小鼠中显示出最小的致病性.
研究的目的:
- 建立SARS-CoV-2 Omicron BA.5病原发生的动物模型.
- 调查Omicron BA.1和BA.5.5之间的致病性差异.
主要方法:
- 对K18-hACE2转基因小鼠感染SARS-CoV-2 Omicron BA.1和BA.5.5的感染.
- 评估发病率,死亡率,病毒载荷和肺病理.
- 在支气管支气管洗液中分析炎症标志物.
主要成果:
- 奥米克朗BA.5导致显著的发病率,死亡率 (100%在5-8个月大小的小鼠中),体重减轻,以及肺病理,与奥米克朗BA.1.不同.
- 较高的早期病毒载荷与增加的BA.5病原性相关.
- BA.1和BA.5都没有在大脑中复制,与之前的SARS-CoV-2变种不同.
结论:
- 在K18-hACE2小鼠中,SARS-CoV-2 Omicron BA.5建立了致病性表型,为病原和抗病毒研究提供了有价值的模型.
- 对BA.1和BA.5的病原性进行比较分析,揭示了疾病严重程度的病毒决定因素.
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