来自巴西饮用水的Pseudomonas aeruginosa的多样性和流行病学概况,使用多位置序列类型化进行基因定型
Paula Vasconcelos Costa1,2, Janaína Dos Santos Nascimento2, Stephen James Forsythe3
1Institute of Technology in Immunobiologicals, Oswaldo Cruz Foundation, Rio de Janeiro/RJ, 21040-900, Brazil.
Letters in applied microbiology
|September 22, 2023
概括
某些与人类感染有关的Pseudomonas aeruginosa序列类型 (ST) 在巴西瓶装水中被检测到. 这凸显了饮用水作为这些细菌潜在的污染途径.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 环境科学 环境科学
背景情况:
- Pseudomonas aeruginosa 是一种格拉姆阴性细菌,经常与水源性疾病有关.
- 了解P. aeruginosa的遗传多样性和分布对于公共卫生监测至关重要.
研究的目的:
- 调查特定的P. aeruginosa序列类型 (ST) 与巴西饮用水污染之间的关联.
- 为了确定P. aeruginosa在商业化饮用水中的潜在公共卫生风险.
主要方法:
- 使用了Pseudomonas PubMLST数据库,其中包含8358个菌株 (1938-2023年).
- 应用多部位序列类型 (MLST) 和eBURST分析来表征细菌分离物.
- 分析了219个巴西的隔离物,重点是从水源中回收的.
主要成果:
- 在巴西的水样中确定了八种P. aeruginosa的ST:STs 252, 1417, 1605, 2502, 2620, 3078和3312.
- 发现STs 252,1417和3078此前已从全球临床病例中分离出来.
- 通过eBURST分析,ST1605和ST2620与已知的感染人类的STs进行了聚类.
结论:
- 与人类感染相关的特定P. aeruginosaSTs在巴西的瓶装饮用水中被检测到.
- 瓶装饮用水可能成为致病性P. aeruginosa菌株传播的重要载体.
- 这一发现强调了需要加强对饮用水供应中的微生物污染的监测.
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