患有轻度自主皮质醇分泌的患者脊椎骨折的风险增加
Vittoria Favero1, Cristina Eller-Vainicher2, Valentina Morelli3
1Department of Medical Biotechnology and Translational Medicine, University of Milan, 20100 Milan, Italy.
The Journal of clinical endocrinology and metabolism
|September 22, 2023
概括
患有上腺意外瘤和轻度自主皮质醇分泌 (MACS) 的患者患脊椎骨折 (VFx) 的风险明显更高. 这项研究证实,MACS是这些患者VFx发育的关键因素.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 放射学 放射学是一门学科.
背景情况:
- 上腺意外瘤 (AI) 和轻度自主皮质醇分泌 (MACS) 与脊椎骨折 (VFx) 风险之间的关联尚不清楚.
- 了解这种关系对于患者管理和风险分层至关重要.
研究的目的:
- 调查AI和MACS患者脊椎骨折 (VFx) 的患病率和发病率.
- 确定MACS是否是该人群中VFx的独立风险因素.
主要方法:
- 一项追溯的横截面和纵向研究,涉及意大利四个内分泌学单位的444名患者 (横截面) 和126名患者 (纵向).
- 评估包括血清皮质醇 (1毫克德甲测试),骨矿物密度 (BMD) 通过DXA,以及脊椎骨折 (VFx) 评估通过X射线.
主要成果:
- 与没有MACS的患者相比,MACS患者的VFx患病率更高 (62.6%vs22.9%) 和新的VFx发病率更高 (36.4%vs10.0%).
- 马克斯独立地与流行 (OR 5.203) 和事件VFx (RR 4.561) 相关,而不考虑其他风险因素,如年龄,BMI,BMD和2型糖尿病.
结论:
- 轻度自主皮质醇分泌 (MACS) 的上腺意外瘤 (AI) 在女性和男性中显著增加了脊椎骨折 (VFx) 的风险.
- 这些发现强调了评估AI和MACS患者骨健康的重要性.
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