内学活跃的性结肠炎与无症状的动脉样性血管疾病有关:一项病例对照研究
Juan Lasa1,2, Ezequiel Nazario2, Gonzalo De Sanctis1
1Gastroenterology Department, Centro de Educación Médica e Investigación Clínica, Buenos Aires, Argentina.
Inflammatory bowel diseases
|September 22, 2023
概括
与健康人相比,患有性结肠炎 (UC) 和活跃炎症的患者患无症状动脉样硬化,特别是增加内膜介质厚度 (IMT) 的风险更高.
科学领域:
- 心血管医学 心血管医学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫媒介疾病中的慢性炎症与动脉样硬化疾病风险的增加有关.
- 关于性结肠炎 (UC) 患者无症状动脉样硬化患病率及其与疾病活性的关系的数据有限.
研究的目的:
- 为了比较无症状动脉样硬化病在年轻UC患者的患病率与健康对照,有或没有粘膜愈合 (MH).
- 调查UC疾病活动与亚临床动脉样硬化之间的关联.
主要方法:
- 阿根廷布宜诺斯艾利斯的一项观察性研究包括60名UC患者 (18-50岁) 和60名健康对照.
- 带和大腿部超声波评估了动脉样硬化病变和内心介质厚度 (IMT).
- 动脉样硬化疾病和异常IMT的患病率在各组之间进行了比较.
主要成果:
- 在没有MH的UC患者,MH的UC患者和对照组之间,在动脉样硬化病变流行率上没有发现显著差异 (3.7%vs0%vs6.67%).
- 然而,与对照组相比,没有MH的UC患者在至少一个血管区域中显示出异常IMT的患病率显著更高 (48.15%vs26.67%).
结论:
- 与对照组相比,性结肠炎患者具有活跃的粘膜炎症,与对照组相比,无症状的股骨或动脉血管疾病的可能性显著增加.
- 在UC中活性炎症与亚临床动脉样硬化有关,突出了对心血管风险评估的需要.
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