大脑-肠轴:侵入性和非侵入性神经刺激,限制和潜在的治疗方法
Fatemeh Hesampour1, Charles N Bernstein2,3, Jean-Eric Ghia1,2,3,4
1Immunology, University of Manitoba, Winnipeg, Canada.
Inflammatory bowel diseases
|September 22, 2023
概括
神经刺激 (VNS) 通过减少炎症,为炎症性肠病 (IBD) 提供了一种有前途的新方法. 通过皮肤进行耳膜VNS等非侵入性方法可能为IBD患者提供长期缓解.
科学领域:
- 胃肠病学 胃肠病学
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 炎症性肠病 (IBD) 是一种无法治愈的慢性疾病,常常导致反复发炎和病变.
- 目前的IBD治疗提供了暂时的缓解,但无法诱导长期缓解,需要新的治疗策略.
- 迷走神经 (VN) 在大脑-肠轴中起着至关重要的作用,其功能受损与IBD病变有关.
研究的目的:
- 审查迷走神经刺激 (VNS) 对治疗炎症性肠病 (IBD) 的潜在治疗益处和缺点.
- 探索非侵袭性穿皮耳迷走神经刺激 (ta-VNS) 的作用,作为IBD的潜在治疗方法.
主要方法:
- 关于迷走神经刺激 (VNS) 和其对炎症和胃肠道疾病的影响现有文献的综述.
- 分析VNS在调节免疫反应和细胞因子生产中的机制.
- 检查非侵入性VNS技术,特别是通过皮肤的耳膜VNS (ta-VNS).
主要成果:
- 神经刺激 (VNS) 通过抑制促炎性细胞因子的产生,显示出显著的抗炎作用.
- 静脉神经系统可以恢复受损的脑肠轴通信,这对于维持IBD的肠道平衡至关重要.
- 非侵入性ta-VNS为提供VNS治疗提供了潜在的安全和有效的方法.
结论:
- 神经刺激 (VNS) 是炎症性肠病 (IBD) 的一个有前途的治疗途径,为实现长期缓解提供了一种新的方法.
- 非侵入性经皮耳VNS值得进一步研究,作为IBD患者寻求传统疗法替代方案的可行治疗选择.
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