在自然感染或接种疫苗后患COVID-19的风险
Anne-Marie Rick1, Matthew B Laurens2, Ying Huang3
1Department of Pediatrics, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
EBioMedicine
|September 22, 2023
概括
之前的SARS-CoV-2感染和混合免疫力为COVID-19提供了显著的保护. 疫苗接种仍然是针对症状和严重疾病提供强有力的保护的最安全策略.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 疫苗学 疫苗学 疫苗学
背景情况:
- COVID-19疫苗是有效的,但第三阶段试验往往忽视了对先前感染或混合免疫的保护.
- 来自协调的美国疫苗试验的个体患者数据为研究这些保护作用提供了独特的机会.
研究的目的:
- 描述之前的SARS-CoV-2感染和对COVID-19的混合免疫的保护效果.
- 为了比较这种保护与疫苗诱导的免疫力在流行病的早期.
主要方法:
- 对Moderna,AstraZeneca,Janssen和Novavax的COVID-19疫苗试验进行后期分析.
- 参与者按感染状况 (没有与以前) 和治疗 (安慰剂与疫苗) 进行分组.
- 通过RT-PCR确认的COVID-19是主要结果,计算了原始和调整后的疗效指标.
主要成果:
- 之前的感染将未来COVID-19的风险降低了92%与没有先前感染相比.
- 混合免疫在单剂量詹森参与者中提供了比单剂量疫苗更好的保护.
- 所有的疫苗接种,以前的感染和混合免疫力都给予了对严重的COVID-19的近乎完全的保护.
结论:
- 之前的感染,混合免疫力和两剂疫苗接种在早期的三角洲变种期间对症状和严重的COVID-19进行了实质性的保护.
- 疫苗接种是最安全的保护方法,作为自然感染的可靠替代品.
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