消费非营养甜味剂阿塞苏尔法酸盐增加了中心早期青春期的风险
Hung-Tsung Wu1, Chi-Chen Chiang2, Chung-Teng Wang1
1Department of Internal Medicine, School of Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Journal of hazardous materials
|September 22, 2023
概括
高消费的非营养甜味剂阿硫酸 (AceK) 可能会增加女孩中部早期青春期 (CPP) 的风险. AceK还加速了老鼠的青春期,并在体外影响了GnRH神经元活动.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 全球早期青春期和非营养甜味剂 (NNS) 消费的增加需要了解它们的潜在联系.
- 硫酸 (AceK) 是一种广泛使用的NNS,但它对青春期发育的具体影响尚未得到充分证实.
研究的目的:
- 调查ACEK消费与青春期前女孩中部早发性青春期 (CPP) 之间的关联.
- 探索AceK在动物和细胞模型中对青春期开始和性腺激素释放激素 (GnRH) 表达的机制影响.
主要方法:
- 在台湾青春期纵向研究 (2018-2022) 中,分析了884名女孩 (6-12岁) 的数据,评估了AceK摄入量和CPP风险.
- 在小鼠体内研究,包括从怀孕到断奶期间的AceK消费和脑内内注射.
- 在体外研究中使用N44下丘脑神经元细胞来检查AceK对活性氧物种 (ROS),蛋白激酶A (PKA) 和GnRH表达的作用.
主要成果:
- 较高的AceK消费 (高于中位数剂量) 与女孩中CPP风险增加显著相关 (OR = 1.88,p=0.003).
- 在老鼠中,AceK暴露加速了青春期的开始,并增加了大脑GnRH的表达.
- 在下丘脑神经元中,AceK提高了ROS的产生,激活了PKA,随后增加了GnRH的表达.
结论:
- 在青春期前的女孩中,AceK的消费可能是发展中部早熟青春期的危险因素.
- 这些发现表明,潜在的机制涉及氧化应激和GnRH途径在大脑中的激活.
- 在接近青春期的儿童食用含有AceK的产品时,建议谨慎使用.
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