来自瘤的内皮细胞:子宫内膜症的重要病因因素
Yishan Dong1, Ming Zhang1, Jun OuYang1
1Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center of Nanjing Medical University, Changzhou, Jiangsu Province, China.
Archives of medical research
|September 22, 2023
概括
子宫内膜异位症 (EMS) 涉及瘤衍生的内皮细胞 (ECs) 的增加,并增强了血管生成. 基因EFNB2与EMS进展和患者复发率更高有关.
科学领域:
- 生殖生物学 生殖生物学
- 细胞和分子生物学是细胞和分子生物学.
- 基因组学就是基因组学.
背景情况:
- 子宫内膜异位症 (EMS) 是一种复杂的妇科疾病,具有显著的细胞异质性.
- 单细胞RNA测序 (scRNA-seq) 提供了一种强大的方法来剖析EMS中的细胞多样性.
- 这项研究旨在创建EMS细胞签名的详细的转录形状.
研究的目的:
- 使用scRNA-seq.来描述子宫内膜异位症的细胞格局.
- 为了识别特定的细胞类型和与宫外子宫内膜组织相关的分子标记.
- 研究内皮细胞和特定基因在EMS病原和复发中的作用.
主要方法:
- 在3名子宫内膜异位症患者的eutopic (EM) 和ectopic (EC) 子宫内膜组织上进行了scRNA-seq.
- 用特定细胞类型的标记基因识别和注释细胞群.
- 进行了差异基因表达分析和关键标记物的临床验证.
主要成果:
- 鉴定出了代表多种细胞类型的30个不同的细胞群.
- 发现了五种内皮细胞 (EC) 亚型,瘤衍生的ECs (IGFBP3+) 在异位病变 (43.8%对16.0%) 中显著增加.
- 与血管生成相关的基因EFNB2在EC上调,与更高的EMS复发率相关.
结论:
- 瘤衍生的EC具有新血管化能力的比例增加是EMS的关键病理特征.
- EFNB2与EMS病原发生有关,并作为疾病复发的潜在生物标志物.
更多相关视频
07:12A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
5.2K
07:20Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
Published on: December 21, 2012
16.0K
相关概念视频
02:17The Tumor Microenvironment
6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
02:30Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
02:38Mitogens and the Cell Cycle
6.5K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
02:07Oogenesis
63.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.8K