美国国税局在癌症进展中的战略参与
Mehnaz Ahmed1, Tannishtha Biswas1, Susmita Mondal1
1Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata, 700073, West Bengal, India.
Biochemical and biophysical research communications
|September 22, 2023
概括
胰岛素受体基质 (IRS) 蛋白质是癌症的关键调节剂,特别是在前列腺,卵巢,乳腺,结肠和肺癌中. 本综述总结了二十年来关于IRS参与癌症进展和转移的研究.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 细胞信号传递 细胞信号传递
背景情况:
- 胰岛素受体基质 (IRS) 作为支架蛋白,对于启动下游信号在与胰岛素受体 (IR) 结合时至关重要.
- 蛋白质水平和稳定性通过翻译后的修改,包括酸化和糖化,来调节.
- 胰岛素信号通路在各种癌症中经常受到放松,突出显示IRS是重要的参与者.
研究的目的:
- 在过去二十年中,审查胰岛素受体基质 (IRS) 蛋白在人类主要癌症的发展和进展中的作用.
- 巩固有关IRS参与前列腺,卵巢,乳腺,结肠和肺癌的发现.
- 确定当前知识的差距,并为其他IRS癌症家族成员建议未来的研究方向.
主要方法:
- 关于过去20年发表的研究的文献综述.
- 对研究的分析,重点是癌症中IRS蛋白的表达和功能.
- 与特定癌症类型中的IRS1,IRS2和IRS4相关的发现的综合.
主要成果:
- 在常见的癌症中,IRS蛋白过度表达,包括前列腺癌,卵巢癌,乳腺癌,结肠癌和肺癌.
- IRS1和IRS2与癌症的进展,入侵和转移有关.
- IRS4已成为卵巢,乳腺,结直肠和肺癌的贡献者,关于其在前列腺癌中的作用的数据有限.
结论:
- 胰岛素受体基质蛋白质是多种癌症类型的关键调节者.
- 需要进一步的研究来探索其他IRS家族成员在癌症中的作用.
- 了解癌症的IRS监管可以为治疗策略提供见解.
相关概念视频
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Adaptive Mechanisms in Cancer Cells
5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
Tumor Progression
6.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.4K


