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The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
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基于 evaluation of sarcopenia 的多重功能模型的开发:对 Otassha 研究的横截面调查
Masaharu Murakami1, Hirohiko Hirano2, Masanori Iwasaki3
1Tokyo Metropolitan Institute for Geriatrics and Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan; National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi 474-8511, Japan.
Archives of oral biology
|September 22, 2023
概括
一个新的模型评估了功能,将严重的功能障碍 (S-MMD) 与老年人营养不良和困难联系起来.
科学领域:
- 老年学是一门学科.
- 口腔健康 口腔健康
- 营养科学 营养科学
背景情况:
- 功能对整体健康至关重要,受到牙,塞,肌肉和舌头协调的影响.
- 麻症,与年龄相关的肌肉损失,可能会影响功能.
- 需要一个全面的模型来评估功能障碍.
研究的目的:
- 开发一个全面的功能模型.
- 为了将sarcopenia概念纳入模型.
- 为了验证模型的测量效率.
主要方法:
- 开发了一个集成masseter肌肉质量,闭塞力和混合能力的模型.
- 753名老年人 (平均年龄为73.0±5.1岁) 参加了这项研究.
- 根据AWGS 2019标准,参与者被分为多发性口功能障碍 (MMD) 或严重的MMD (S-MMD) 组. 后勤回归分析了使用血清白蛋白和自我报告的困难的模型有效性.
主要成果:
- 8.1%的参与者患有MMD,3.2%患有S-MMD.
- S-MMD与低血清白蛋白水平 (OR: 3.62) 和自我报告的困难增加 (OR: 2.82) 有显著关联.
结论:
- 开发的模型提供了一种简单的方法来评估MMD.
- 严重的MMD与营养脆弱性和挑战有关,验证了该模型的临床相关性.
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