基于CTP估计的缺血核心:Olea和RAPID软件之间的比较多中心研究
V Yedavalli1, S Kihira2, P Shahrouki2
1Johns Hopkins University School of Medicine, Baltimore, MD, United States.
概括
图像扫描图像 perfusion (CTP) 软件显示,对大血管封闭的缺血核心体积估计有显著差异. 无论是RAPID还是Olea平台,都与最终心脏病发作量相关,超调的大型心脏病发作率较低.
科学领域:
- 神经成像是一种神经成像.
- 脑卒中成像 脑卒中成像
- 脑血管疾病 脑血管疾病
背景情况:
- 大脑输液断层扫描 (CTP) 在大血管封闭 (LVO) 中对内血管治疗 (EVT) 选择至关重要.
- 不同的CTP软件包之间存在不一致的缺血核心体积估计.
- 这项研究比较了由RAPID和Olea软件生成的CTP核心体积.
研究的目的:
- 为了比较 CTP 估计的 RAPID 和 Olea 软件之间的缺血核心体积.
- 评估这些估计与MRI-DWI上的最终心脏病发作体积 (FIV) 的相关性.
- 用多个中风中心的异质数据来评估软件性能.
主要方法:
- 对151名前部循环LVO患者进行CTP和成功EVT的回顾性分析.
- 使用Olea (rCBF < 25%,dTTP > 5s) 和RAPID (rCBF < 30%) 的自动化CTP分析.
- 将CTP估计的核心体积与治疗后MRI-DWI上的FIV进行比较.
主要成果:
- 在Olea (18.7±18.9毫升) 和RAPID (10.5±17.9毫升) 之间,CTP估计的缺血核心体积存在显著差异 (p<0.01).
- 两种软件都显示出与FIV相比较的中度相关性 (RAPID的r=0.38,Olea的r=0.39).
- 强大的软件间相关性 (r=0.864,p < 0.001);低,相同的超调用大核心 (>70 mL) 率.
结论:
- 在Olea和RAPID软件之间,CTP估计的缺血核心体积存在实质性的差异.
- 两种平台都显示出与最终心脏病发作体积的可比相关性.
- 对于这两种软件来说,超调的大型心脏病发作量率很低,而且相似.
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