在大血管封闭中,左心房扩大与不良的大脑附带体之间的关联
Md Manjurul Islam Shourav1, Bhrugun Anisetti1, Raja R Godasi1
1Department of Neurology, Mayo Clinic, Jacksonville, Florida, United States.
概括
左心房扩大 (LAE) 与大血管封闭 (LVO) 卒中患者中脑附带的差异有关. 这一发现表明心脑连接可能会影响中风的结果.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 左心房扩大 (LAE) 是心房动的危险因素,是大血管封闭 (LVO) 中风的原因.
- 在缺血事件期间,大脑附带物对保护大脑组织至关重要.
- 结构性心脏病,如LAE,对大脑附带循环的影响尚不清楚.
研究的目的:
- 调查左心房扩大 (LAE) 与大脑附带状态之间的关联.
- 为了确定LAE是否与急性LVO中风患者的脑附带资产不良独立相关.
主要方法:
- 对235名LVO中风患者进行了内血管血栓切除术 (EVT) 的回顾性分析.
- 心声学和计算机断层扫描血管学 (CTA) 用于评估LAE和大脑附带证据.
- 多变量逻辑回归调整为人口统计和血管风险因素.
主要成果:
- 37.9%的患者患有LAE,44.7%的患者有不良的附带因素.
- 患有LAE的患者表现出明显更高的不良附带的流行率 (58.4%与36.3%,P=0.001).
- LAE独立地与不良的大脑附带资产相关 (调整后OR,1.84;P=0.048).
结论:
- 在LVO中风患者中,LAE和不良的大脑附带资产之间存在显著的关联.
- 需要进一步的研究来探索共享的机制,如内皮功能障碍,将心脏和大脑健康联系起来.
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