根据疫苗接种状态对COVID-19住院病人的多国分析
Bronner P Gonçalves1, Waasila Jassat2, Joaquín Baruch1
1ISARIC, Pandemic Sciences Institute, University of Oxford, Oxford, UK.
Med (New York, N.Y.)
|September 22, 2023
概括
接种疫苗的住院COVID-19患者往往比未接种疫苗的患者患上更多的并发病. 介绍和结果的差异在各国之间有很大差异,为资源分配和未来研究提供了信息.
科学领域:
- 传染性疾病 传染性疾病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 针对严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 的疫苗接种并不总是能预防需要住院治疗的严重疾病.
- 目前尚不清楚,住院接种疫苗的患者是否在临床表现,并发症或结局方面与未接种疫苗的患者有所不同.
研究的目的:
- 研究COVID-19的住院接种疫苗和未接种疫苗的患者之间的差异.
- 评估观察到的差异是否是各国的特定环境.
主要方法:
- 分析了来自38个国家的83,163名住院COVID-19患者 (34,843名接种疫苗,48,320名未接种疫苗) 的国际财团数据.
- 在接种疫苗和未接种疫苗的组之间比较患者表现,并发病症和住院死亡风险.
主要成果:
- 未接种疫苗的患者更经常出现典型的COVID-19症状.
- 接种疫苗的患者患上并发症的患病率更高,其中一些与预后较差有关.
- 在医院死亡风险和接种疫苗和未接种疫苗的结果差异方面,观察到国际上显著的差异.
结论:
- 研究结果突出了住院接种疫苗和未接种疫苗的COVID-19患者的不同临床特征.
- 结果将指导未来疫情激增期间的医疗保健资源分配,并为有关疫苗接种对临床形状影响的国际研究提供信息.
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