实验性自粘复合材料中不同功能的单体的作用:聚合动力学,细胞代谢的影响和密封能力
Marta Nunes Ferreira1, Marta Neves Dos Santos1, Inês Fernandes2
1Egas Moniz Center for Interdisciplinary Research (CiiEM); Egas Moniz School of Health & Science, 2829-511 Caparica, Almada, Portugal.
Biomedical materials (Bristol, England)
|September 22, 2023
概括
将功能性单体添加到自粘复合材料 (SAC) 影响聚合和毒性,但不会提高密封能力. 仅基于这些单体的自粘性要求可能值得怀疑.
科学领域:
- 牙科材料科学 牙科材料科学
- 聚合物化学 聚合物化学
- 生物相容性测试 生物相容性测试
背景情况:
- 自粘复合材料 (SAC) 旨在简化牙科程序.
- 功能性单体通常用于增强性能.
- 特定功能单体对SAC性能的影响需要详细评估.
研究的目的:
- 评估不同功能性单体对实验性SACs的聚合动力学的影响.
- 评估这些单体对细胞代谢活性 (细胞毒性) 的影响.
- 为了确定包含各种功能性单体的SAC的密封能力和微泄漏.
主要方法:
- 实验性SACs的配方包括尿二甲酸盐,三乙烯糖醇二甲酸盐和10%的功能性单体:10-甲烯酸二酸,甘酸二甲酸 (GPDM),2-甲酸 (HEMA) 或乙烯酸 (HEAA).
- 聚合动力学分析使用减弱总反射率里埃变换红外光谱 (ATR-FTIR).
- 用MDPC-23细胞进行MTT测定来评估细胞毒性,并在热循环后在人类大的V类腔中评估微泄漏.
主要成果:
- 功能性单体显著影响了最终的单体转换 (DC,max),其中HEMA产生了最高的转换 (64 ± 3%).
- 在100%以下的度下,HEMA和HEAA配方表现出显著的细胞毒性.
- 随着功能性单体的添加,无论老化情况如何,没有观察到微漏或密封能力的显著改善.
结论:
- 虽然功能性单体显然会影响SAC中的聚合动力学和细胞毒性潜力,但它们不会提高密封性能.
- 像MDP和GPDM这样的更大的功能性单体影响了聚合,但由于其酸性而没有增加细胞毒性.
- 复合材料的自粘性要求仅基于功能性单体的含量似乎值得怀疑.
相关概念视频
Polymer Classification: Stereospecificity
2.5K
Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
2.5K
Step-Growth Polymerization: Overview
3.5K
Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
Many natural and synthetic polymers are produced by...
3.5K
Anionic Chain-Growth Polymerization: Overview
2.1K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
2.1K
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)
1.9K
Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
1.9K
Polymers
35.8K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
35.8K
Characteristics and Nomenclature of Copolymers
2.6K
Copolymers are the products obtained from the polymerization of multiple monomer species. So, in a polymer chain itself, there can be multiple repeating units that come from different monomers. The process of synthesizing a polymer from different monomer species is called copolymerization. When two monomers are involved, the polymer is known as a bipolymer. Polymers with three and four monomers are termed terpolymers and quaterpolymers, respectively. Figure 1 depicts the copolymerization of...
2.6K


