口服药物配方中的表面活性辅助剂的安全性
Sam Maher1, Caroline Geoghegan1, David J Brayden2
1School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland.
Advanced drug delivery reviews
|September 22, 2023
概括
本综述探讨了口服药物的表面活性剂如何与肠道相互作用. 虽然一些表面活性剂在实验室测试中会损害肠道细胞,但它们对人类健康的实际影响需要进一步调查.
科学领域:
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
- 材料科学 材料科学 材料科学
背景情况:
- 表面活性剂是用于制药,食品,化品和洗剂的多功能化合物.
- 它们与不同物质相之间的接口相互作用.
- 本综述侧重于口服药物剂型中的表面活性剂辅助剂及其胃肠道 (GI) 通道相互作用.
研究的目的:
- 审查口服药品剂型中表面活性剂辅助剂与肠表皮的相互作用.
- 在不同类型的研究中评估各种表面活性助剂的安全数据.
- 探索减轻表面活性剂对GI表皮的潜在不良影响的因素.
主要方法:
- 对表面活性剂-肠道管道相互作用的体外,体外,临床前动物和人体研究的综述.
- 对口服产品中表面活性剂辅助剂的安全数据的分析.
- 审查关于乳化剂与性结肠炎,代谢障碍和癌症等疾病之间的联系的研究.
主要成果:
- 口服产品中的许多表面活性剂降低了肠道细胞活力,并在临床前模型中改变了屏障完整性.
- 从目前的临床前模型中预测人类安全似乎存在不匹配.
- 有争议的研究表明,某些乳化剂与严重的健康状况之间存在潜在的联系.
结论:
- 口服剂型的表面活性剂辅助剂与肠道相互作用,对肠道表皮有不同的影响.
- 临床前模型显示潜在的危害,但人类安全预测需要仔细考虑.
- 了解这些相互作用对于开发更安全的口服药物输送系统至关重要.
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