考古体促进了大麻二醇的储存和口服输送
Viktor Sedlmayr1, Christina Horn2, David Johannes Wurm2
1TU Wien, Institute of Chemical, Environmental and Bioscience Engineering, Vienna, Austria.
International journal of pharmaceutics
|September 22, 2023
概括
基于脂质的新型纳米载体 - - 考古体显著改善了口服大麻素 (CBD) 输送. 与传统的脂质体相比,这些载体增强了CBD加载,稳定性和细胞吸收,为口服CBD配方提供了有前途的解决方案.
科学领域:
- 药理学 药理学是指药理学的学科.
- 纳米技术纳米技术
- 生物化学 生物化学
背景情况:
- 大麻二醇 (CBD) 具有治疗潜力,但由于胃肠道降解,第一通代谢和水溶性低,其口服生物可用性较差 (6%).
- 传统的素衍生的脂质体,虽然用于疏水性药物输送,但在胃肠道和长期储存期间面临稳定性的挑战.
- 基于乙脂的古体具有独特的化学和结构性质,可以克服口服药物输送中常规脂质体的局限性.
研究的目的:
- 为了比较考古酶体与常规脂质体的疗效,作为大麻素 (CBD) 的口服输送系统.
- 评估关键参数,包括药物负载能力,储存稳定性,在模拟的胃肠道环境中的稳定性和体外细胞吸收.
主要方法:
- 用于CBD封装的考古体和莱西丁衍生的脂质体的比较分析.
- 在化后六个月的储存稳定性的评估.
- 在模拟的胃肠道中评估药物恢复.
- 使用Caco-2细胞进行体外颗粒吸收的评估.
主要成果:
- 与传统的脂质体相比,考古酶体对CBD的药物载荷能力高出6倍.
- 在解冷化后的六个月内,考古酶的配方保持稳定.
- 在模拟的胃肠道中,CBD回收在古体 (57 ± 3%) 中明显高于常规脂质体 (34 ± 1%).
- 在实验室中,Caco-2细胞对考古体的吸收增加了6倍.
结论:
- 与传统的脂质体相比,考古体代表了一种优越的纳米载体系统,用于口服大麻素 (CBD) 输送.
- 加强的稳定性和改善的CBD载荷古体的细胞吸收解决了当前口服CBD配方的关键局限性.
- 考古体为开发更有效的口服药物输送系统提供了一个有希望的策略,用于像CBD这样的疏水化合物.
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