在家族性高胆固醇血症患者中实现治疗目标:现实世界的描述性研究
Simon Faubert1, Martine Paquette1, Alexis Baass2
1Lipids, Nutrition, and Cardiovascular Prevention Clinic of the Montreal Clinical Research Institute, Montreal, Québec, Canada.
Clinical biochemistry
|September 22, 2023
概括
接受常规治疗的家族高胆固醇血症 (FH) 患者的LDL-C目标达到较低. 高强度他类药物改善了结果,但大多数FH患者仍然需要更密集的治疗来预防心血管疾病.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 药理学 药理学是指药理学的学科.
背景情况:
- 家族性高胆固醇血症 (FH) 是一种遗传性疾病,导致高心血管风险.
- 立方体和ezetimibe是FH的第一线治疗方法,但在北克,实际目标的实现尚未得到充分研究.
研究的目的:
- 评估在初级预防中达到LDL-C目标而没有PCSK9抑制剂的FH患者比例.
- 评估常规降脂疗法在FH中的有效性.
主要方法:
- 在蒙特利尔临床研究院的脂质临床上进行了回顾性研究.
- 包括225名分子定义或临床诊断的FH患者.
- 分析了基于治疗强度的LDL-C目标实现率.
主要成果:
- 只有三分之一的FH患者达到LDL-C目标<2.5 mmol/L.
- 服用高强度他类药物的患者实现这一目标的可能性是高两倍.
- 男人和女人在实现目标方面没有显著差异.
结论:
- 传统的降脂治疗在FH患者中显示了不可接受的低目标实现率.
- 在大多数FH病例中,目前的治疗方法可能不足以充分预防心血管疾病.
- 对FH强化治疗策略的进一步研究是有必要的.
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