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Updated: Jul 16, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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短距离末端切除需要ATAD5介导的PCNA卸载,以实现忠实的同源重组

Su Hyung Park1,2, Namwoo Kim1,3, Nalae Kang1

  • 1Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Korea.

Nucleic acids research
|September 22, 2023
PubMed
概括

ATAD5蛋白卸载PCNA,使短程DNA末端切除成为可能,这是同源重组 (HR) 修复的关键步骤. 它的缺陷会损害HR,有利于容易出错的DNA修复途径.

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