减轻SARS-CoV-2患者症状严重程度和持续时间的食补充剂:双盲随机对照试验
Dugald Seely1,2,3, Mark Legacy4,2, Ellen Conte4
1Patterson Institute for Integrative Oncology Research, Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada dseely@thechi.ca.
BMJ open
|September 22, 2023
概括
这项研究发现,维生素C,维生素D3,维生素K2和的组合并没有显著改善COVID-19门诊患者的健康结果. 需要进一步的研究来确认这些食补充剂在治疗COVID-19方面的临床效用.
科学领域:
- 营养免疫学 营养免疫学
- 传染性疾病 传染性疾病
- 临床试验 临床试验
背景情况:
- COVID-19 构成了全球健康威胁,需要除了疫苗之外的有效治疗方法,特别是针对社区患者.
- 饮食补充剂正在探索呼吸道感染,初步数据表明在COVID-19管理中可能有好处.
- 这项研究调查了一种特定的补充剂组合对其对COVID-19门诊患者的影响.
研究的目的:
- 评估联合补充剂 (维生素C,D3,K2和) 在改善COVID-19门诊患者的整体健康状况和减少症状负担方面的疗效.
- 评估这些补充剂对各种次要健康结果的影响,包括症状的严重程度和持续时间.
主要方法:
- 这是一项双盲,安慰剂控制,随机化试验,涉及诊断为COVID-19的门诊患者.
- 参与者每天接受补充剂组合 (维生素C,D3,K2,酸盐) 或安慰剂,持续21天,随访期为12周.
- 主要结局是自我报告的整体健康状况;次要结局包括症状严重程度,住院率和死亡率.
主要成果:
- 该研究因招聘挑战而过早停止,从而限制了统计能力.
- 在补充剂和安慰剂组之间的初级结果 (整体健康) 中没有观察到临床或统计学上显著的差异.
- 二次结果,包括健康状况,症状持续时间和住院频率,也没有显著差异.
结论:
- 与安慰剂相比,维生素C,维生素D3,维生素K2和酸的研究组合对COVID-19门诊患者没有显示出显著的临床益处.
- 由于可行性问题,试验的提前终止妨碍了最终确定疗效的能力.
- 需要进一步的研究来探索这些补充剂在管理COVID-19中的潜在临床实用性.
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