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癌症风险人群中的循环瘤细胞作为癌症拦截工具

María José Serrano¹, Christian Rolfo², José Expósito-Hernandez¹

¹GENYO Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Liquid Biopsy and Cancer Interception Group, Granada, Spain; IBS Granada, Biosanitary Research Institute, Spain; Comprehensive Oncology Division, Virgen de las Nieves University Hospital, Granada, Spain.

International review of cell and molecular biology

|September 22, 2023

概括

癌症拦截使用液体活检来非侵入性地检测瘤前阶段. 循环瘤细胞 (CTC) 是早期癌症检测和监测风险人群治疗反应的关键.

科学领域:

在瘤学瘤学.
生物标志物生物标志物
预防癌症预防癌症

背景情况:

癌症拦截 (CI) 为高风险个体的癌症预防和治疗提供了一个新的策略.
它专注于检测和治疗前瘤状况,可能改善结果.
像活检这样的传统方法是侵入性的,而CI的目标是减少侵入性的方法.

研究的目的:

探索癌症拦截的基础科学研究.
突出循环瘤细胞 (CTC) 作为CI的液体活检 (LB) 工具的作用.
讨论CTC查在癌症风险人群中的临床影响.

主要方法:

使用液体活检 (LB) 技术进行非侵入性采样.
专注于循环瘤细胞 (CTC) 的检测和分析.
审查关于CI和CTC查的科学文献.

主要成果:

液体活检 (LB) 能够频繁,非侵入性地监测癌症进展.
循环瘤细胞 (CTC) 可以在早期癌症和前恶性病变中检测到.
CTC在瘤发育的早期阶段起着重要作用.

结论:

癌症拦截 (CI) 利用液体活检 (LB) 和循环瘤细胞 (CTC) 进行早期癌症检测和管理.
通过CTC进行的非侵入性监测比传统的诊断方法具有优势.
在风险人群中,CI显示为积极癌症护理的前性.

关键词:

癌症拦截癌症拦截预防癌症预防癌症循环中的瘤细胞.液体活检液体活检风险人口风险人口

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