这是迈向个性化免疫抑制的第一步
Klemens Budde1, Lionel Rostaing2
1Department of Nephrology and Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany.
Kidney international
|September 22, 2023
概括
使用人口药理动力学和药理遗传学的个性化塔克罗利斯剂量,在移植中提供了显著的好处. 这种方法可以防止低于最佳的药物暴露,并降低成本,为精准医学铺平道路.
科学领域:
- 科和免疫学 科和免疫学
- 药物基因组学和药物代谢
背景情况:
- 塔克罗利斯是移植中基石免疫抑制剂.
- 目前的剂量策略可能会导致低于最佳的暴露,增加排斥或毒性的风险.
- 个性化剂量为优化结果提供了希望.
研究的目的:
- 提供支持个性化塔克罗利斯剂量算法的证据.
- 突出人口药理动力学和药理遗传学在优化塔克罗利斯治疗中的作用.
- 倡导在移植中整合精准医学原则.
主要方法:
- 开发一个整合人口药理动学的剂量算法.
- 包括药物遗传标记,以量身定制药物暴露.
- 评估与个性化剂量相关的临床结果.
主要成果:
- 拟议的算法证明了改善塔克罗利斯剂量的潜力.
- 个性化剂量可以减轻暴露不足和过度暴露的风险.
- 通过优化药物管理,有可能节省成本.
结论:
- 基于药理动力学和药理遗传学的个性化塔克罗利斯剂量算法提供了显著的好处.
- 这种方法代表了在移植中迈向精准医学的一步.
- 进一步整合先进的评估对于个性化免疫抑制疗法至关重要.
相关概念视频
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:27Tumor Immunotherapy
551
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
551
01:40Cell-mediated Immune Responses
68.7K
Overview
68.7K
01:25Immunodeficiency Diseases
970
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
970
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
186
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
186
01:27Cytotoxic T Cells-mediated Immune Response
956
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
956