在接受化疗的癌症患者中,相位角度,身体生活质量和功能
Camila Conde Frio1, Jéssica Härter2, Leonardo Pozza Santos3
1Post-Graduate Program in Nutrition and Food, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
Clinical nutrition ESPEN
|September 22, 2023
概括
在癌症患者的化疗后,相角 (PhA) 显著下降. 较低的PhA与减少的身体生活质量和功能相关,突出其预后价值.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 生物物理学的生物物理.
背景情况:
- 营养不良和身体组成的改变,包括低肌肉质量,在癌症患者中很普遍.
- 阶段角 (PhA) 是一种生物电阻分析 (BIA) 参数,反映了细胞膜完整性和营养状况.
- PhA已经显示出作为癌症患者功能和生活质量相关的预后指标的潜力.
研究的目的:
- 评估化疗对癌症患者相角 (PhA) 的影响.
- 为了比较化疗治疗前后的PhA值.
- 评估PhA作为肌肉质量的替代品与生活质量,功能性和营养风险之间的相关性.
主要方法:
- 一项纵向研究涉及175名癌症患者进行首次化疗治疗.
- 阶段角 (PhA) 测量是在初始评估和治疗后进行的.
- 统计分析包括t测试,ANOVA进行群组比较,以及线性回归来评估PhA变化和相关性.
主要成果:
- 从初始评估到最终评估 (p=0.018) 观察到平均PhA的显著下降.
- 最初和最后的PhA与生活质量的物理领域有显著的相关性 (r=0.29,p<0.001和r=0.19,p=0.021).
- PhA还与功能评分和总患者生成主观全球评估 (PG-SGA) 评分有显著的相关性.
结论:
- 阶段角 (PhA) 是一种有价值的指标,在癌症患者的化疗后下降.
- 在这个患者群体中,PhA作为身体生活质量和功能性的预测指标.
- 这些发现支持PhA在监测接受化疗的癌症患者中的使用.
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