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乳制品消费和肺癌风险:一个前性分析
Lan N Đoàn1, Chenxiao Hu2, Zhenzhen Zhang3
1College of Health, Health Promotion and Health Behavior Program, Oregon State University, Corvallis, OR, USA; Department of Population Health, Section for Health Equity, NYU Grossman School of Medicine, New York, NY, USA.
摄入发酵乳制品可能会降低肺癌风险,而全脂牛奶的摄入可能会增加风险. 这项研究探讨了美国队列中的乳制品消费和肺癌发病率.
科学领域:
- 营养流行病学 营养流行病学
- 在瘤学瘤学.
- 饮食科学 饮食科学
背景情况:
- 有限且不一致的证据表明,乳制品,乳脂和乳糖摄入量与肺癌风险之间存在关联.
- 需要进行前性研究来澄清这些关系.
研究的目的:
- 调查各种乳制品摄入量与肺癌风险之间的潜在关联.
- 研究乳制品脂肪和乳糖在肺癌发展中的作用.
主要方法:
- 通过前列腺,肺,结肠直肠和卵巢癌查试验 (PLCO) 队列的数据进行了前性分析.
- 评估饮食摄入量,包括乳制品,使用经过验证的饮食历史问卷.
- 多变量考克斯回归模型用于计算危险比率 (HR) 和95%置信区间 (CI).
主要成果:
- 在101,709名成年人中,发现了1583例肺癌病例.
- 总乳制品摄入量与肺癌风险没有显著关联.
- 发酵乳制品的摄入与肺癌风险相反相关 (HR:0.85,95% CI:0.72-0.99).
- 偏爱全脂牛奶与偏爱低脂牛奶相比,与更高的肺癌风险有关 (HR:1.24,95% CI:1.03-1.49).
结论:
- 摄入发酵乳制品可能与肺癌风险降低有关.
- 作为饮料的全脂牛奶消费可能与肺癌风险增加有关.
- 对这些关联背后的分子机制进行进一步研究是有必要的.
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